Tse Wai S, Bond Alyson J
Division of Psychological Medicine, Institute of Psychiatry, King's College London, UK.
J Psychopharmacol. 2003 Jun;17(2):189-95. doi: 10.1177/0269881103017002007.
Reboxetine is a novel antidepressant with a selective action on noradrenaline. In addition to its efficacy in depression, it has been found to improve social adaptation. The objective of this study was to assess the specific social behavioural effects of reboxetine which might be associated with social adaptation. Ten pairs of healthy volunteers took part in a randomized double-blind, crossover study of 2 weeks treatment with reboxetine (4 mg b.d.) and placebo with a 2-week washout period. In each pair, one person (subject) took the tablets and the other (flatmate) received no treatment. On the last day of each treatment period, the subjects socially interacted with a stranger (a confederate behaving as a responsive person) in a stranger-dyadic social interaction paradigm. After the interaction, subjects played the Mixed-Motive game, which measures cooperative behaviour and communication, with the confederate. Subjects read a short story before and after the social interaction. The flatmates evaluated the social behaviour of the subjects before and at the end of the two treatment periods. On reboxetine, the subjects were rated to be significantly more agreeable and cooperative (passive participant) and less submissive by their flatmates. They showed significantly less eye contact with the confederate in the social interaction paradigm and gave significantly fewer helplessness messages during the game. They spoke faster on the reading task after the social interaction. This study provides evidence that reboxetine increases cooperative social behaviour and increases social drive, which might be important for social adaptation.
瑞波西汀是一种对去甲肾上腺素具有选择性作用的新型抗抑郁药。除了对抑郁症有效外，还发现它能改善社会适应能力。本研究的目的是评估瑞波西汀可能与社会适应相关的特定社会行为效应。十对健康志愿者参与了一项随机双盲交叉研究，接受为期2周的瑞波西汀（每日2次，每次4毫克）治疗和安慰剂治疗，中间有2周的洗脱期。在每对中，一人（受试者）服用药物，另一人（室友）不接受治疗。在每个治疗期的最后一天，受试者在陌生人二元社会互动范式中与一名陌生人（一名表现出有反应的人）进行社会互动。互动后，受试者与该陌生人玩混合动机游戏，该游戏用于测量合作行为和沟通能力。受试者在社会互动前后阅读一篇短篇小说。室友在两个治疗期开始前和结束时对受试者的社会行为进行评估。服用瑞波西汀后，室友对受试者的评价是明显更随和、更合作（被动参与者）且更少顺从。在社会互动范式中，他们与陌生人的眼神接触明显减少，在游戏中发出的无助信息也明显减少。社会互动后，他们在阅读任务中的语速更快。这项研究提供了证据，表明瑞波西汀能增加合作性社会行为并增强社会驱动力，这可能对社会适应很重要。
