Tse Wai S, Bond Alyson J
Section of Clinical Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, King's College, London SE5 8AF, UK.
Psychopharmacology (Berl). 2002 May;161(3):324-30. doi: 10.1007/s00213-002-1049-7. Epub 2002 Apr 4.
Deficiencies in serotonin function have been associated with irritability and aggression but enhancing serotonin has also been shown to promote social status and affiliative behaviour in non-human primates and more recently in humans.
To investigate the effects of citalopram, a selective serotonin reuptake inhibitor (SSRI), on social behaviour with a flatmate and a stranger.
Ten pairs of healthy volunteers took part in a randomized double-blind crossover study of 2 weeks treatment with citalopram (20 mg/day) and placebo with a 2-week washout period. In each pair, one person (subject) took the tablets and the other (flatmate) received no treatment. On the last day of each treatment period, the subjects socially interacted with a confederate behaving as a responsive person in a stranger-dyadic social interaction paradigm. After the interaction, subjects played the Mixed-motive game, which measures cooperative behaviour and communication, with the confederate. The flatmates evaluated the social behaviour of the subjects before and at the end of the treatment periods.
On citalopram, the subjects were rated as significantly less submissive by their flatmates and they showed a dominant pattern of eye contact in the stranger-dyadic social interaction paradigm. They also reduced the number of points they awarded themselves and sent more cooperative messages during the game.
These results indicate that administration of an SSRI can modify social status in different interactions and increase affiliative behaviour. They implicate a role for serotonin in modulating social aspects of behaviour.
血清素功能缺陷与易怒和攻击性有关，但提高血清素水平也已被证明可促进非人类灵长类动物以及最近在人类中的社会地位和亲和行为。
研究选择性血清素再摄取抑制剂（SSRI）西酞普兰对与室友及陌生人社交行为的影响。
十对健康志愿者参与了一项随机双盲交叉研究，接受为期2周的西酞普兰（20毫克/天）治疗及安慰剂治疗，中间有2周的洗脱期。每对中，一人（受试者）服用药物，另一人（室友）不接受治疗。在每个治疗期的最后一天，受试者在陌生人二元社交互动范式中与一名表现出反应性的同谋进行社交互动。互动后，受试者与同谋玩混合动机游戏，该游戏用于测量合作行为和沟通情况。室友在治疗期开始和结束时对受试者的社交行为进行评估。
服用西酞普兰后，受试者被室友评定为顺从性显著降低，并且在陌生人二元社交互动范式中表现出主导性的眼神接触模式。他们在游戏中也减少了给自己的得分，并发送了更多合作信息。
这些结果表明，服用SSRI可在不同互动中改变社会地位并增加亲和行为。这表明血清素在调节行为的社会方面发挥作用。
