Granville David J, Gottlieb Roberta A
The Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Curr Med Chem. 2003 Aug;10(16):1527-33. doi: 10.2174/0929867033457214.
Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors. The current review outlines current knowledge related to the role of VDAC in the regulation of cell death and speculates on possible therapeutic applications through VDAC modulation.
电压依赖性阴离子通道（VDAC）是线粒体外膜的主要成分。在过去几年里，关于VDAC在线粒体外膜通透性及随后促凋亡因子释放中所起作用，出现了支持和反对的几种假说及机制。本综述概述了与VDAC在细胞死亡调控中作用相关的现有知识，并推测了通过调节VDAC可能的治疗应用。
