Herwald H, Mörgelin M, Dahlbäck B, Björck L
Department of Cell and Molecular Biology, Section for Molecular Pathogenesis, Lund University, Lund, Sweden.
J Thromb Haemost. 2003 Feb;1(2):284-91. doi: 10.1046/j.1538-7836.2003.00105.x.
Invasive and toxic infections caused by Streptococcus pyogenes are connected with high morbidity and mortality. Typical symptoms of these infections are hypotension, edema formation, tissue necrosis, and bleeding disorders. Here we report that components of the coagulation system including fibrinogen, factors V, XI, and XII, and H-kininogen, are assembled at the surface of S. pyogenes through specific interactions with bacterial surface proteins. In plasma environment, absorption of fibrinogen by S. pyogenes causes a hypocoagulatory state resulting in prolonged clotting times and impaired fibrin network formation. Moreover, the binding of coagulation factors and the subsequent activation of the coagulation system at the bacterial surface lead to the formation of a fibrin network covering S. pyogenes bacteria adhering to epithelial cells. The results suggest that interactions between S. pyogenes and components of the coagulation system contribute to some of the symptoms seen in severe infections caused by this important human pathogen.
化脓性链球菌引起的侵袭性和毒性感染与高发病率和死亡率相关。这些感染的典型症状包括低血压、水肿形成、组织坏死和出血性疾病。在此我们报告，凝血系统的成分，包括纤维蛋白原、V、XI和XII因子以及H-激肽原，通过与细菌表面蛋白的特异性相互作用，聚集在化脓性链球菌表面。在血浆环境中，化脓性链球菌对纤维蛋白原的吸附导致低凝状态，从而延长凝血时间并损害纤维蛋白网络的形成。此外，凝血因子的结合以及随后在细菌表面的凝血系统激活导致形成覆盖附着在上皮细胞上的化脓性链球菌细菌的纤维蛋白网络。结果表明，化脓性链球菌与凝血系统成分之间的相互作用导致了由这种重要人类病原体引起的严重感染中出现的一些症状。
