Påhlman Lisa I, Malmström Erik, Mörgelin Matthias, Herwald Heiko
Department of Clinical Sciences, Lund, Section for Clinical and Experimental Infection Medicine, Lund University, SE-22184 Lund, Sweden.
Microbiology (Reading). 2007 Aug;153(Pt 8):2458-2464. doi: 10.1099/mic.0.2006/003285-0.
Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. Analysis of the resulting clots by transmission electron microscopy revealed that the cells were covered with a fibrin network that seemed to originate from the cell surface. Taken together, the results imply an important role for M proteins in the induction of haemostatic disorders in invasive streptococcal infectious diseases.
由重要病原体化脓性链球菌引起的侵袭性感染通常与人类宿主的凝血紊乱有关，在严重情况下可能发展为危及生命的弥散性血管内凝血状态。在本研究中，将M1蛋白添加到人体血液或纯化的外周血单核细胞中会导致促凝血活性呈剂量依赖性增加，这是由单核细胞上组织因子的上调介导的。通过透射电子显微镜对形成的凝块进行分析发现，细胞被似乎源自细胞表面的纤维蛋白网络所覆盖。综上所述，这些结果表明M蛋白在侵袭性链球菌感染性疾病引起的止血障碍诱导中起重要作用。
