Cano J, Guarro J, Mayayo E, Fernandez-Ballart J
Unitat de Microbiologia, Facultat de Medicina, Universitat de Barcelona, Tarragona, Spain.
J Med Vet Mycol. 1992;30(6):413-20.
The experimental pathogenicity of Scedosporium inflatum (three isolates) and Scedosporium apiospermum (one strain) was determined following intraperitoneal and intravenous injection into immunosuppressed and normal mice. Immunosuppressed animals were treated with cortisone acetate. The results show that the strains studied displayed positive tropism to kidney and brain. In the histopathological study of the first organ, we initially observed abscesses at the glomerular level and later in the renal pelvis. In the brain, we detected large areas with necrosis, which produced important neurological disorders resulting in convulsive movements and a stiff neck. The isolates of S. inflatum were more virulent (45% mortality) than S. apiospermum (16% mortality). The inoculation method did not significantly affect the mortality rate of the mice by either fungus. In infections caused by S. inflatum the percentage of immunosuppressed mice which died was higher in comparison to that of the untreated group. On the other hand no differences were observed in the mortality of either group animals inoculated with S. apiospermum.
通过对免疫抑制小鼠和正常小鼠进行腹腔注射和静脉注射，测定了膨胀瓶霉（3个分离株）和伪阿利什霉（1个菌株）的实验致病性。免疫抑制动物用醋酸可的松进行处理。结果表明，所研究的菌株对肾脏和脑表现出阳性嗜性。在对第一个器官的组织病理学研究中，我们最初在肾小球水平观察到脓肿，随后在肾盂中也观察到脓肿。在脑中，我们检测到大面积坏死，这导致了严重的神经功能障碍，表现为抽搐运动和颈部僵硬。膨胀瓶霉的分离株比伪阿利什霉更具毒性（死亡率为45%比16%）。接种方法对两种真菌导致的小鼠死亡率均无显著影响。在由膨胀瓶霉引起的感染中，免疫抑制小鼠的死亡百分比高于未处理组。另一方面，接种伪阿利什霉的两组动物在死亡率上未观察到差异。
