Mamont B, Sawicka B
Kliniki Choroby Wieńcowej Instytutu Kardiologii, Warszawie.
Kardiol Pol. 1992 Nov;37(11):283-6.
Functional and biochemical parameters of the haemostatic system in coronary heart disease (CHD) are still not well defined. Epidemiological studies indicate a positive correlation between fibrinogen (F) level and cardiovascular morbidity and mortality. Two independent ways of factor VII activation in the coagulation cascade suggest a special role of this factor in clot forming (Fig. 1). 22 patients (pts) under 55 yrs with a history of myocardial infarction (MT) and 22 healthy control men were studied for F level and factor VII activity (fVIIa). We found increased F level (M-363.3 mg/dl) and high level of VIIa (M-150.3%) in plasma of pts with a history of MI. Furthermore a strong positive correlation between fVIIa in plasma and F level (r = 0.62), serum cholesterol (chol) (r = 0.35), serum triglycerides (tg) (r = 0.32) (Tab. 2) was bound. Calculations were performed for all subjects: pts and control combined in one group. A possible influence of diet on fVIIa level is discussed. One should consider the usefulness of oral anticoagulants in the prophylaxis of MT.
冠心病（CHD）止血系统的功能和生化参数仍未明确界定。流行病学研究表明纤维蛋白原（F）水平与心血管疾病的发病率和死亡率之间存在正相关。凝血级联反应中因子VII激活的两种独立方式表明该因子在血栓形成中具有特殊作用（图1）。对22例55岁以下有心肌梗死（MT）病史的患者和22名健康对照男性进行了F水平和因子VII活性（fVIIa）研究。我们发现有MI病史患者的血浆中F水平升高（中位数-363.3mg/dl）和VIIa水平升高（中位数-150.3%）。此外，血浆中fVIIa与F水平（r = 0.62）、血清胆固醇（chol）（r = 0.35）、血清甘油三酯（tg）（r = 0.32）之间存在强正相关（表2）。对所有受试者（患者和对照组合并为一组）进行了计算。讨论了饮食对fVIIa水平的可能影响。应考虑口服抗凝剂在预防MT中的作用。
