Oms P, Bruniquel F, Puech L, Delhon A
Division des Maladies Cardiovasculaires I, Centre de Recherche Pierre Fabre, Castres, France.
Methods Find Exp Clin Pharmacol. 1992 Sep;14(7):531-5.
The present study analyzed the effects of the new hypolipidemic agent, F 2833, in male golden Syrian hamsters fed a standard diet or a diet supplemented with 0.06% cholesterol and 20% coconut oil. F 2833 did not detectably modify the blood lipid parameters studied in hamsters receiving the standard diet. After 28 days, the hyperlipidemic diet in untreated animals significantly increased plasma cholesterol, triglycerides and phospholipids (by 91, 138 and 61%, respectively) and in the different lipoprotein classes. Treatment with F 2833 (150 and 300 mg/kg/day) caused a dose-dependent reduction of the blood lipid parameters studied. At the higher dose, this decrease was significant for cholesterol (27%), triglycerides (48%) and plasma phospholipids (27%). With regard to the different classes of lipoproteins, a significant drop in cholesterol was observed in VLDL (38%) and LDL (29%), while that in HDL (22%) was not significant. Triglycerides were significantly lowered in all lipoprotein classes with a more pronounced effect in the VLDL pool (53%). F 2833 thus decreased plasma lipids in hamsters that were fed on hyperlipidemic diet to normal values observed in animals fed a standard diet. These results confirm and extend findings previously obtained in other animal species in which F 2833 was also shown to be an effective hypolipidemic drug.
本研究分析了新型降血脂药物F 2833对雄性叙利亚金黄地鼠的影响，这些地鼠分别喂食标准饮食或添加了0.06%胆固醇和20%椰子油的饮食。F 2833对接受标准饮食的地鼠所研究的血脂参数没有明显影响。28天后，未治疗动物的高脂血症饮食显著增加了血浆胆固醇、甘油三酯和磷脂（分别增加了91%、138%和61%）以及不同脂蛋白类别的含量。用F 2833（150和300毫克/千克/天）治疗导致所研究的血脂参数呈剂量依赖性降低。在较高剂量下，胆固醇（27%）、甘油三酯（48%）和血浆磷脂（27%）的降低具有显著性。关于不同类别的脂蛋白，极低密度脂蛋白（VLDL）（38%）和低密度脂蛋白（LDL）（29%）中的胆固醇显著下降，而高密度脂蛋白（HDL）中的胆固醇下降（22%）不显著。所有脂蛋白类别的甘油三酯均显著降低，在极低密度脂蛋白池中效果更明显（53%）。因此，F 2833将喂食高脂血症饮食的地鼠的血浆脂质降低至喂食标准饮食的动物所观察到的正常水平。这些结果证实并扩展了先前在其他动物物种中获得的发现，在这些物种中F 2833也被证明是一种有效的降血脂药物。
