Shanthi S, Parasakthy K, Deepalakshmi P D, Devaraj S N
Department of Biochemistry, University of Madras.
Indian J Biochem Biophys. 1994 Apr;31(2):143-6.
Tincture of Crataegus (TCR), an alcoholic extract of the berries of Crataegus oxyacantha, when administered to rats fed a hyperlipidemic diet (HLD), could prevent the elevation in plasma lipid levels. A significant decrease in lipid deposits in liver and aorta was also observed. Analysis of the plasma lipoprotein profile showed that TCR produced remarkable reduction in the increased levels of cholesterol, triglycerides and phospholipids in the low density lipoprotein (LDL) and very low density lipoprotein (VLDL) fractions in hyperlipidemic rats. Histological examination showed severe fatty vacuolation and degeneration of liver of HLD fed rats. TCR administration had an ameliorating effect on these changes. Agarose gel electrophoretic pattern of plasma lipoproteins also indicated that the drug brought down the raised levels of the atherogenic beta-lipoproteins in hyperlipidemic rats.
山楂酊（TCR）是山楂（Crataegus oxyacantha）浆果的酒精提取物，给高脂饮食（HLD）喂养的大鼠服用时，可预防血浆脂质水平升高。还观察到肝脏和主动脉脂质沉积显著减少。血浆脂蛋白谱分析表明，TCR使高脂血症大鼠低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）组分中胆固醇、甘油三酯和磷脂升高的水平显著降低。组织学检查显示，HLD喂养大鼠的肝脏出现严重脂肪空泡化和变性。给予TCR对这些变化有改善作用。血浆脂蛋白的琼脂糖凝胶电泳图谱也表明，该药物降低了高脂血症大鼠中致动脉粥样硬化的β-脂蛋白升高的水平。
