John Chandy C, Zickafoose Joseph S, Sumba P Odada, King Christopher L, Kazura James W
Center for Global Health and Disease and Division of Pediatric Infectious Disease, Case Western Reserve University School of Medicine and Rainbow Babies and Children's Hospital, Cleveland, Ohio 44106, USA.
Infect Immun. 2003 Aug;71(8):4320-5. doi: 10.1128/IAI.71.8.4320-4325.2003.
Immunoglobulin G (IgG) antibodies to three vaccine candidate preerythrocytic Plasmodium falciparum antigens were evaluated in children and adults in an epidemic-prone highland area of Kenya during rainy (high-transmission) and dry (low-transmission) seasons. The frequencies and median levels of IgG antibodies to circumsporozoite protein (CSP) and thrombospondin-related adhesive protein (TRAP) were compared to the frequencies and median levels of IgG antibodies to liver-stage antigen 1 (LSA-1) reported previously. The frequencies and median levels of IgG antibodies to CSP and TRAP were similar in children and adults in the rainy season, but they were lower in children than in adults in the dry season. The frequencies and median levels of antibodies to LSA-1 were lower in children than in adults in both the rainy and dry seasons. Antibodies to CSP and LSA-1 were primarily members of the IgG1 and IgG3 subclasses, while antibodies to TRAP were primarily members of the IgG3 and IgG4 subclasses. In a treatment-reinfection study following dry season testing, antibodies to TRAP were associated with a trend toward protection from infection in children (P = 0.051) but not in adults. Antibodies to LSA-1 and CSP did not correlate with protection in children or adults. In this highland area of Kenya with unstable transmission, IgG antibodies to preerythrocytic P. falciparum antigens vary in subjects by age and season, and the protective effects of these antibodies against infection may be different in adults and children.
在肯尼亚一个易发生疟疾流行的高地地区，于雨季（高传播季节）和旱季（低传播季节）对儿童和成人中针对三种候选疫苗的恶性疟原虫前体红细胞期抗原的免疫球蛋白G（IgG）抗体进行了评估。将针对环子孢子蛋白（CSP）和血小板反应蛋白相关黏附蛋白（TRAP）的IgG抗体的频率和中位数水平，与先前报道的针对肝期抗原1（LSA-1）的IgG抗体的频率和中位数水平进行了比较。在雨季，儿童和成人中针对CSP和TRAP的IgG抗体的频率和中位数水平相似，但在旱季，儿童中的这些抗体频率和中位数水平低于成人。在雨季和旱季，儿童中针对LSA-1的抗体频率和中位数水平均低于成人。针对CSP和LSA-1的抗体主要是IgG1和IgG3亚类的成员，而针对TRAP的抗体主要是IgG3和IgG4亚类的成员。在旱季测试后的治疗再感染研究中，针对TRAP的抗体与儿童感染保护趋势相关（P = 0.051），但在成人中不相关。针对LSA-1和CSP的抗体在儿童或成人中与保护作用均无关联。在肯尼亚这个传播不稳定的高地地区，针对恶性疟原虫前体红细胞期抗原的IgG抗体在不同年龄和季节的人群中存在差异，并且这些抗体对感染的保护作用在成人和儿童中可能有所不同。
