Institute for Glycomics, Griffith University, Southport, QLD, Australia.
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia.
Front Immunol. 2019 Feb 1;10:135. doi: 10.3389/fimmu.2019.00135. eCollection 2019.
In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Here, we review the key aspects of immunity against parasites, liposome design considerations and their current application in the development of a malaria vaccine.
在疫苗的开发中，需要考虑到能够引发先天免疫和随后的适应性免疫反应的能力。减毒活疫苗自然能实现这一点，而灭活疫苗和亚单位疫苗通常需要通过传递系统和/或佐剂提供额外的帮助。脂质体是一种有吸引力的抗原佐剂/传递系统。在这里，我们回顾了针对寄生虫的免疫的关键方面、脂质体设计的考虑因素以及它们在疟疾疫苗开发中的当前应用。
