小鼠中主要组织相容性复合体依赖性对新型隐球菌的易感性
Major histocompatibility complex-dependent susceptibility to Cryptococcus neoformans in mice.
作者信息
McClelland Erin E, Granger Donald L, Potts Wayne K
机构信息
Biology Department, University of Utah, Salt Lake City, Utah 84112, USA.
出版信息
Infect Immun. 2003 Aug;71(8):4815-7. doi: 10.1128/IAI.71.8.4815-4817.2003.
Abstract
To evaluate the role of major histocompatibility complex (MHC) genes in the resistance to Cryptococcus neoformans, we conducted infection experiments in MHC-congenic strains of mice. Significant MHC-dependent susceptibility differences were found among homozygotes and heterozygotes. This study is the first experimental demonstration of MHC-dependent susceptibility to C. neoformans infections in mice and indicates that MHC genes can be important in host resistance.
摘要
为了评估主要组织相容性复合体（MHC）基因在抵抗新型隐球菌感染中的作用，我们在MHC同基因系小鼠中进行了感染实验。在纯合子和杂合子之间发现了显著的MHC依赖性易感性差异。本研究首次通过实验证明了小鼠对新型隐球菌感染存在MHC依赖性易感性，并表明MHC基因在宿主抗性中可能具有重要作用。
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