Dromer F, Yeni P, Charreire J
INSERM U. 283, Hôpital Cochin, Paris, France.
Immunogenetics. 1988;28(6):417-24. doi: 10.1007/BF00355373.
Cryptococcus neoformans is responsible for opportunistic infections in patients with cellular immune defects. However, C. neoformans-specific capsular polysaccharide antibodies have been shown to participate in host defenses during cryptococcosis. We investigated the humoral response after primary immunization in various inbred strains of mice and the genetic control. Our data strengthen the arguments for the T-independent type-2 nature of cryptococcal antigen, since CBA/N mice were unable to produce specific antibodies. They show that the influence of the genetic background is predominant for the good response with at least four independent autosomal genes governing this response, including an Igh control as reported for other polysaccharides. Immunization of intra-H-2 recombinant mice on a B10 background allowed us to identify a major histocompatibility complex control located in the subregion E alpha. The genetic control of antibody production following immunization with cryptococcal polysaccharide might explain the high variability of humoral responses during cryptococcosis.
新型隐球菌可导致细胞免疫缺陷患者发生机会性感染。然而，已证明新型隐球菌特异性荚膜多糖抗体在隐球菌病期间参与宿主防御。我们研究了各种近交系小鼠初次免疫后的体液反应及遗传控制。我们的数据支持了隐球菌抗原具有2型非T细胞依赖性的观点，因为CBA/N小鼠无法产生特异性抗体。数据表明，遗传背景的影响对于良好反应起主导作用，至少有四个独立的常染色体基因控制这种反应，包括如其他多糖所报道的免疫球蛋白重链（Igh）控制。对B10背景的H-2重组小鼠进行免疫，使我们能够确定位于Eα亚区的主要组织相容性复合体控制。用隐球菌多糖免疫后抗体产生的遗传控制可能解释了隐球菌病期间体液反应的高度变异性。
