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牛支原体7群的细胞表面抗原与纤溶酶原结合并激活纤溶酶原。

Cell surface antigens of Mycoplasma species bovine group 7 bind to and activate plasminogen.

作者信息

Bower Kylie, Djordjevic Steven P, Andronicos Nicholas M, Ranson Marie

机构信息

Department of Biological Sciences, University of Wollongong, Wollongong, New South Wales 2522, Australia.

出版信息

Infect Immun. 2003 Aug;71(8):4823-7. doi: 10.1128/IAI.71.8.4823-4827.2003.

DOI:10.1128/IAI.71.8.4823-4827.2003
PMID:12874368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC166029/
Abstract

Mycoplasma species bovine group 7 bound plasminogen at the cell surface in a lysine-dependent manner. Cell-bound plasminogen was rapidly activated to plasmin by exogenous urokinase, and this activity was associated with plasminogen binding capacity. Binding assays using plasminogen modified with a trifunctional cross-linking agent revealed several binding proteins.

摘要

牛支原体7组以赖氨酸依赖的方式在细胞表面结合纤溶酶原。细胞结合的纤溶酶原被外源性尿激酶迅速激活为纤溶酶，并且这种活性与纤溶酶原结合能力相关。使用三功能交联剂修饰的纤溶酶原进行的结合试验揭示了几种结合蛋白。

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本文引用的文献

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Characterization of the interaction of bovine plasmin with Streptococcus uberis.
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Vet Microbiol. 1998 Mar 15;61(1-2):121-35. doi: 10.1016/s0378-1135(98)00179-5.
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Increased plasminogen binding is associated with metastatic breast cancer cells: differential expression of plasminogen binding proteins.纤溶酶原结合增加与转移性乳腺癌细胞相关：纤溶酶原结合蛋白的差异表达。
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