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A mutated CCR5 gene may have favorable prognostic implications in MS.

作者信息

Kantor Rami, Bakhanashvili Mary, Achiron Anat

机构信息

Division of Infectious Diseases, Sheba Medical Center, Tel-Hashomer, Israel.

出版信息

Neurology. 2003 Jul 22;61(2):238-40. doi: 10.1212/01.wnl.0000069921.20347.9e.

DOI:10.1212/01.wnl.0000069921.20347.9e
PMID:12874407
Abstract

The authors investigated the association between Delta32CCR5, a mutated allele of the chemokine receptor CCR5, and disease progression in 256 patients with multiple sclerosis (MS). The mutated allele frequency in the study cohort was 7.4%, similar to that reported in the general Israeli population. Progression to disability was prolonged in Delta32CCR5 homozygotes and heterozygotes compared with MS patients with the CCR5 wild-type genotype (p < 0.005). Mutated CCR5 allele may be considered a favorable prognostic factor in MS.

摘要

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