青少年中与快乐面部表情相关的杏仁核激活：一项3T功能磁共振成像研究。
Amygdalar activation associated with happy facial expressions in adolescents: a 3-T functional MRI study.
作者信息
Yang Tony T, Menon Vinod, Reid Amy J, Gotlib Ian H, Reiss Allan L
机构信息
Department of Psychiatry, University of California-San Diego School of Medicine, USA.
出版信息
J Am Acad Child Adolesc Psychiatry. 2003 Aug;42(8):979-85. doi: 10.1097/01.CHI.0000046886.27264.BA.
OBJECTIVE
To study the possible role of the amygdala in the recognition of happy and sad facial expressions in adolescents aged 13 to 17 years.
METHOD
Twelve healthy adolescents (6 females and 6 males) underwent noninvasive 3-Tesla functional magnetic resonance imaging while viewing pictures of happy, sad, and neutral facial expressions.
RESULTS
Happy faces produced significant bilateral amygdalar activation when compared with neutral faces (p <.05, corrected). Sad faces relative to neutral did not produce significant amygdalar activation.
CONCLUSIONS
These results extend the role of the amygdala in adolescents to include the recognition of happy facial expressions. They demonstrate the feasibility of using happy facial expressions to noninvasively study amygdalar function in adolescents and establish a baseline against which the amygdalar response to emotional stimuli in several psychiatric conditions may be compared.
目的
研究杏仁核在13至17岁青少年识别快乐和悲伤面部表情中可能发挥的作用。
方法
12名健康青少年（6名女性和6名男性）在观看快乐、悲伤和中性面部表情图片时接受了无创3特斯拉功能磁共振成像检查。
结果
与中性面孔相比，快乐面孔引起双侧杏仁核显著激活（p <.05，校正后）。悲伤面孔相对于中性面孔未引起杏仁核显著激活。
结论
这些结果扩展了杏仁核在青少年中的作用，使其包括对快乐面部表情的识别。它们证明了使用快乐面部表情来无创研究青少年杏仁核功能的可行性，并建立了一个基线，可据此比较几种精神疾病中杏仁核对情绪刺激的反应。
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