Femiano F
Reparto di Patologia Orale, Prima Clinica Odontostomatologica, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Napoli, Italy.
Minerva Stomatol. 2003 Apr;52(4):187-90.
In the presence of immune-mediated vesiculo-bullous diseases, the oral pathologist should focus his attention not only on the diagnosis and treatment of the case, but should particularly investigate the state of genetic predisposition in relation to the HLA haplotype structure and look for the possible trigger factors for the disease. The detection of the trigger may guarantee a faster cure with a minimum therapeutic contribution. In the search for triggering factors, the drugs that are traditionally incriminated such as ACE inhibitors, Fans, antibiotics (penicillin and penicillamine), substances with -SH groups, tranquillisers, are not always involved in inducing vesiculo-bullous diseases. Substances considered innocuous are often to blame. We present a case of mucous-cutaneous bullous pemphigoid induced by an anti-hypertensive of the sartan group, valsartan.
在免疫介导的水疱大疱性疾病中，口腔病理学家不仅应关注病例的诊断和治疗，还应特别研究与HLA单倍型结构相关的遗传易感性状态，并寻找该疾病可能的触发因素。检测到触发因素可能以最小的治疗投入确保更快治愈。在寻找触发因素时，传统上被归责的药物，如血管紧张素转换酶（ACE）抑制剂、解热镇痛药、抗生素（青霉素和青霉胺）、含巯基的物质、镇静剂，并不总是引发水疱大疱性疾病的原因。被认为无害的物质往往是罪魁祸首。我们报告一例由沙坦类抗高血压药缬沙坦诱发的黏膜皮肤类天疱疮病例。
