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对氯苯丙氨酸处理后大鼠对小鼠的种间攻击性

Interspecies aggressiveness of rats towards mice after the application of p-chlorophenylalanine.

作者信息

Roliński Z

出版信息

Pol J Pharmacol Pharm. 1975 Oct;27(Suppl):223-9.

PMID:128746
Abstract

The administration of pCPA (400 mg/kg) induces in 30% of Wistar rats the potentiation of interspecies aggressiveness and develops in them the instinct to kill mice. It can be supposed that 5-HT system inhibits aggressive behaviour in this type of aggressiveness. Applying mouse killing test it has been stated that cholinergic receptor blockers (atropine, scopolamine) suppress the predatory instinct towards mice in killer rats and the pilocarpine, the cholinomimetic, develops such instinct in rats which previously did not kill mice. The results of the mouse killing test indicate that cholinergic system affects this type of aggressiveness in rats. For the time being, it is difficult to state the correlation between 5-HT and cholinergic system in this type of aggressive behaviour in rats.

摘要

给予对氯苯丙氨酸(400毫克/千克)可使30%的Wistar大鼠出现种间攻击性增强,并使其产生捕杀小鼠的本能。可以推测,5-羟色胺系统在这种攻击行为中抑制攻击行为。应用小鼠捕杀试验表明,胆碱能受体阻滞剂(阿托品、东莨菪碱)可抑制杀手大鼠对小鼠的捕食本能,而拟胆碱药毛果芸香碱则可使先前不捕杀小鼠的大鼠产生这种本能。小鼠捕杀试验结果表明,胆碱能系统影响大鼠的这种攻击行为。目前,很难说明5-羟色胺与胆碱能系统在大鼠这种攻击行为中的相关性。

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1
Interspecies aggressiveness of rats towards mice after the application of p-chlorophenylalanine.对氯苯丙氨酸处理后大鼠对小鼠的种间攻击性
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