Zharkovskiĭ A M, Allikmets K Kh
Zh Vyssh Nerv Deiat Im I P Pavlova. 1977 Nov-Dec;27(6):1303-7.
In male albino rats the electrolytic lesions of the dorsal and median raphe nuclei of the mesencephalon diminished apomorphine-induced aggressiveness (number of attacks, aggressive posture latencies) but didn't influence significantly the intensity of the stereotypy. Both the blockator of tryptophane hydroxylase parachlorophenylamine (PCPA) and 1-tryptophane did not exert any influence on behavioral effects of apomorphine. The raphe-lesion as well as PCPA decreased the level of serotonin and 5-hydroxyindoleacetic acid in the rat forebrain. PCPA decreased in raphe-lesioned rats the dopamine level too. M-cholinoblocking agent atrophine enhanced apomorphine-induced aggressiveness and stereotypy. The blockator of cholinesterase physostigmine had opposite effects. The results suggest that apomorphine induced aggressiveness depends on serotoninergic and cholinergic activity in the brain and there exists a functional link between these neuromediator systems in the CNS.
在雄性白化大鼠中，中脑背侧和中缝核的电解损伤降低了阿扑吗啡诱导的攻击性（攻击次数、攻击姿势潜伏期），但对刻板行为的强度没有显著影响。色氨酸羟化酶阻断剂对氯苯丙氨酸（PCPA）和L-色氨酸对阿扑吗啡的行为效应均无任何影响。中缝核损伤以及PCPA均降低了大鼠前脑中血清素和5-羟吲哚乙酸的水平。PCPA也降低了中缝核损伤大鼠的多巴胺水平。M胆碱阻断剂阿托品增强了阿扑吗啡诱导的攻击性和刻板行为。胆碱酯酶阻断剂毒扁豆碱则产生相反的效果。结果表明，阿扑吗啡诱导的攻击性取决于大脑中的5-羟色胺能和胆碱能活性，并且中枢神经系统中这些神经介质系统之间存在功能联系。
