[Analysis of apomorphine aggessiveness and stereotypy: role of serotonin- and cholinergic systems of the brain].

In male albino rats the electrolytic lesions of the dorsal and median raphe nuclei of the mesencephalon diminished apomorphine-induced aggressiveness (number of attacks, aggressive posture latencies) but didn't influence significantly the intensity of the stereotypy. Both the blockator of tryptophane hydroxylase parachlorophenylamine (PCPA) and 1-tryptophane did not exert any influence on behavioral effects of apomorphine. The raphe-lesion as well as PCPA decreased the level of serotonin and 5-hydroxyindoleacetic acid in the rat forebrain. PCPA decreased in raphe-lesioned rats the dopamine level too. M-cholinoblocking agent atrophine enhanced apomorphine-induced aggressiveness and stereotypy. The blockator of cholinesterase physostigmine had opposite effects. The results suggest that apomorphine induced aggressiveness depends on serotoninergic and cholinergic activity in the brain and there exists a functional link between these neuromediator systems in the CNS.