Cozzi F, Zucchetta P, Durigon N, Marzola M C, Bullo A, Favaro M, Bui F, Todesco S
Cattedra e Divisione di Reumatologia, Università di Padua, Italy.
Reumatismo. 2003;55(2):86-92.
To define the prevalence and severity of esophageal involvement in systemic sclerosis (SSc) and its relationship with the different clinical forms and ANA specificities of the disease.
A hundred consecutive patients with SSc, 48 with cutaneous limited, 26 with intermediate and 26 with diffuse form of disease, 49 with anti-centromere and 37 with anti-Scl70 ANA pattern, were submitted to scintigraphy using a semisolid orally ingested bolus to detect esophageal hypomotility.
An impairment of esophageal function has been observed in 68% of SSc patients. Esophageal dysmotility was significantly more frequent and severe in patients with cutaneous diffuse and intermediate forms of SSc and with anti-Scl70 ANA pattern.
Esophageal involvement is very common in SSc. The scintigraphy confirms to be a useful and non invasive diagnostic method; moreover it permits to quantify the severity of the esophageal dysmotility by analyzing both global and segmental function.
明确系统性硬化症（SSc）食管受累的患病率和严重程度，及其与该疾病不同临床类型和抗核抗体（ANA）特异性的关系。
连续纳入100例SSc患者，其中48例为皮肤局限性，26例为中间型，26例为弥漫型，49例抗着丝点抗体阳性，37例抗Scl70 ANA模式阳性，口服半固体团块进行闪烁扫描以检测食管动力不足。
68%的SSc患者存在食管功能损害。在皮肤弥漫型和中间型SSc患者以及抗Scl70 ANA模式阳性患者中，食管运动障碍明显更频繁且严重。
食管受累在SSc中非常常见。闪烁扫描证实是一种有用的非侵入性诊断方法；此外，通过分析整体和节段性功能，它还能量化食管运动障碍的严重程度。
