Koff Stephen A
Section of Urology, Children's Hospital, Ohio State University Medical Center, Columbus, Ohio, USA.
APMIS Suppl. 2003(109):7-12.
Hydronephrosis is generally considered a pathologic process, and especially in infancy is widely viewed as caused by obstruction, potentially injurious to the kidney and in need of expeditious surgical treatment. However a number of clinical and experimental studies suggest exactly the opposite: that hydronephrosis is not pathological but actually a compensating mechanism designed to protect the kidney from high pressures and renal damage. Furthermore, because hydronephrosis in the infant involves an already compliant and distensible renal pelvis it appears to be uniquely beneficial. Herein the experimental basis for a counterargument challenging the harmful effects of hydronephrosis will be presented.
肾积水通常被认为是一种病理过程，尤其是在婴儿期，人们普遍认为它是由梗阻引起的，可能会对肾脏造成损害，需要迅速进行手术治疗。然而，一些临床和实验研究却表明了完全相反的观点：肾积水并非病理性的，实际上是一种旨在保护肾脏免受高压和肾损伤的代偿机制。此外，由于婴儿期的肾积水涉及已经顺应性好且可扩张的肾盂，它似乎具有独特的益处。本文将介绍质疑肾积水有害影响的反论点的实验依据。
