Klimov L Ia
Stavropol State Medical Academy.
Eksp Klin Gastroenterol. 2003(2):99-104, 120.
We determined the dependence of the frequency of lactose intolerance, particular features of the clinical presentation and laboratory showings on lactase deficiency on the basis of a complex clinical, anamnestic and laboratory study of 149 children with chronic gastroduodenal pathologies. It was established that the prevalence of lactose intolerance in children with superficial gastroduodenitis amounts to 58.8%, in children with erosive gastroduodenitis--66.7% and in children with stomach ulcers--83.3%. During the oral lactose load and a subsequent laboratory study we revealed an impairment of the hydrolytic function of small intestines accompanied by an increase of fecal excretion of carbohydrates (lactose and monosaccharides) as well as a considerable enhancement of bacterial fermentation. The detection of fecal excretion of the total glycoprotein hexoses characterizes a disorder of the morphofunctional state of the gastrointestinal tract in children with intestinal enzymopathies.
我们在对149例患有慢性胃十二指肠疾病的儿童进行综合临床、既往史及实验室研究的基础上，确定了乳糖不耐受的发生率、临床表现的特殊特征以及实验室检查结果与乳糖酶缺乏之间的相关性。结果表明，浅表性胃十二指肠炎症患儿的乳糖不耐受发生率为58.8%，糜烂性胃十二指肠炎症患儿为66.7%，胃溃疡患儿为83.3%。在口服乳糖负荷试验及随后的实验室检查过程中，我们发现小肠水解功能受损，伴有碳水化合物（乳糖和单糖）粪便排泄增加以及细菌发酵显著增强。检测粪便中总糖蛋白己糖可反映患有肠道酶病的儿童胃肠道形态功能状态的紊乱。
