Yang Y, He M, Cui H, Bian L, Wang Z
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Chin Med J (Engl). 2000 Dec;113(12):1129-32.
To determine lactose metabolism and lactase activity in Chinese children of different ages, prevalence of lactase deficiency (LD), and lactose intolerance (LI).
All 1168 healthy subjects between 3 and 13 years were recruited from schools in four large cities in China. They were screened by a 25 g lactose tolerance test. Some subjects were challenged with 50 g milk powder on different days. Both indicators, the expiratory H2 concentration and intolerance symptoms, were analyzed.
LD occurred in 38.5% of children in the 3-5 year age group, and 87% of the 7-8 year and 11-13 year old groups. The age of occurrence for LD may be at 7-8 years among Chinese children. The prevalence of LI among Chinese children was 12.2% at age 3-5 years, 33.1% at age 7-8 years, and 30.5% at age 11-13 years, respectively.
The results demonstrate that LD is very common in Chinese children from these four cities. LD and LI have a dose dependent response: lactose absorption and symptoms are based on lactase activity. The relationship between breast feeding history (or the history of cow milk intake) and lactase activity among Chinese children has not been established.
测定不同年龄段中国儿童的乳糖代谢及乳糖酶活性、乳糖酶缺乏（LD）和乳糖不耐受（LI）的患病率。
从中国四个大城市的学校招募了1168名3至13岁的健康受试者。通过25克乳糖耐量试验对他们进行筛查。一些受试者在不同日期接受50克奶粉的激发试验。对呼气氢气浓度和不耐受症状这两项指标进行分析。
3至5岁年龄组中38.5%的儿童发生LD，7至8岁和11至13岁组中这一比例为87%。中国儿童发生LD的年龄可能在7至8岁。中国儿童中LI的患病率在3至5岁时为12.2%，7至8岁时为33.1%，11至13岁时为30.5%。
结果表明，在这四个城市的中国儿童中LD非常普遍。LD和LI存在剂量依赖性反应：乳糖吸收和症状取决于乳糖酶活性。中国儿童母乳喂养史（或牛奶摄入史）与乳糖酶活性之间的关系尚未确立。
