Assanasen Paraya, Baroody Fuad M, Haney Lauran, deTineo Marcy, Naureckas Edward, Solway Julian, Naclerio Robert M
Section of Otolaryngology--Head and Neck Surgery, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA.
Acta Otolaryngol. 2003 Jun;123(5):627-36.
To evaluate in humans the mechanisms underlying the increase in nasal mucosal temperature following immersion of the feet in warm water (42 degrees C).
The nasal mucosal temperature of subjects was measured whilst their feet were immersed in warm water.
The nasal mucosal temperature rose quickly on immersion and dissipated equally fast on removal of the feet from warm water. Intranasal lidocaine raised the mucosal temperature slightly after application, but also blocked the feet warming-induced increase in nasal mucosal temperature, suggesting a neural reflex. Whereas the cutaneous-nasal reflex stimulates a transient parasympathetic response, acetylcholine does not seem to contribute to the more prolonged increase in nasal mucosal temperature following immersion of the feet in warm water. Warming of the feet probably leads to a loss of alpha-sympathetic activity of nasal blood vessels and an increase in nasal mucosal temperature because application of phenoxybenzamine, an alpha-sympathetic blocking agent, to the nasal mucosa increased the nasal mucosal temperature.
Our data suggest that the increase in nasal mucosal temperature after warming of the feet is mediated by a neural reflex, which is caused by loss of sympathetic activity of the nasal vasculature and a possible additional contribution of a long-acting parasympathetic mediator.
评估人体在双脚浸入温水（42摄氏度）后鼻黏膜温度升高的潜在机制。
在受试者双脚浸入温水时测量其鼻黏膜温度。
双脚浸入温水时鼻黏膜温度迅速上升，双脚从温水中移出后温度同样迅速消散。鼻内应用利多卡因后黏膜温度略有升高，但也阻断了因足部升温引起的鼻黏膜温度升高，提示存在神经反射。虽然皮肤 - 鼻反射刺激短暂的副交感神经反应，但乙酰胆碱似乎并未促成双脚浸入温水后鼻黏膜温度更持久的升高。足部升温可能导致鼻血管α - 交感神经活性丧失以及鼻黏膜温度升高，因为向鼻黏膜应用α - 交感神经阻滞剂酚苄明会增加鼻黏膜温度。
我们的数据表明，足部升温后鼻黏膜温度升高是由神经反射介导的，这是由鼻血管交感神经活性丧失以及一种长效副交感神经介质可能的额外作用引起的。
