Bayles Kenneth W
Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, ID 83844-3052, USA.
Trends Microbiol. 2003 Jul;11(7):306-11. doi: 10.1016/s0966-842x(03)00144-6.
The Staphylococcus aureus cid and lrg operons have been shown to encode putative membrane proteins that are involved in the regulation of murein hydrolase activity and penicillin tolerance. Cid proteins enhance murein hydrolase activity and penicillin sensitivity, whereas Lrg proteins have an inhibitory effect on these processes. It has been proposed that the Cid and Lrg proteins function in a way analogous to bacteriophage-encoded holins and antiholins, respectively, which control the timing of bacteriophage-induced lysis. This article explores the possibility that the Cid-Lrg regulatory system controls bacterial programmed cell death using a molecular strategy that it is functionally analogous to that mediated by the eukaryotic Bcl-2 family of apoptosis regulatory proteins.
金黄色葡萄球菌cid和lrg操纵子已被证明可编码假定的膜蛋白，这些蛋白参与胞壁质水解酶活性的调节和青霉素耐受性。Cid蛋白增强胞壁质水解酶活性和青霉素敏感性，而Lrg蛋白对这些过程具有抑制作用。有人提出，Cid和Lrg蛋白的功能方式分别类似于噬菌体编码的孔蛋白和抗孔蛋白，它们控制噬菌体诱导裂解的时间。本文探讨了Cid-Lrg调节系统使用一种分子策略控制细菌程序性细胞死亡的可能性，该策略在功能上类似于由真核细胞凋亡调节蛋白Bcl-2家族介导的策略。
