Kiemeneij I M, de Leeuw F-E, Ramos L M P, van Gijn J
Department of Neurology, University Medical Centre Utrecht, St Elisabeth Medical Centre Tilburg, Netherlands.
J Neurol Neurosurg Psychiatry. 2003 Aug;74(8):1126-7. doi: 10.1136/jnnp.74.8.1126.
A 24 year old woman presented with a sudden excruciating headache mimicking an acute vascular event. She had undergone a lung transplantation because of cystic fibrosis and was receiving maintenance treatment with tacrolimus and prednisone. Ancillary investigation excluded vascular causes. Magnetic resonance imaging demonstrated hyperintense lesions in the infratentorial and parieto-occipital regions consistent with posterior leucencephalopathy syndrome. Both her clinical condition improved and the lesions disappeared completely after withdrawal of tacrolimus, suggesting that her condition could be explained by a tacrolimus encephalopathy.
一名24岁女性因突发剧烈头痛前来就诊，症状类似急性血管事件。她因囊性纤维化接受了肺移植手术，目前正在接受他克莫司和泼尼松的维持治疗。辅助检查排除了血管性病因。磁共振成像显示幕下和顶枕区有高信号病变，符合后部白质脑病综合征。停用他克莫司后，她的临床症状改善，病变完全消失，提示她的病情可能是由他克莫司脑病所致。
