Kim Min-Seon, Yoon Cho-Ya, Park Kyeong-Han, Shin Chan-Soo, Park Kyong-Soo, Kim Seong-Yeon, Cho Bo-Youn, Lee Hong-Kyu
Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.
Neuroreport. 2003 Jul 18;14(10):1317-20. doi: 10.1097/01.wnr.0000078703.79393.d2.
Ghrelin, a newly identified gut hormone, has been implicated in the regulation of food intake and energy homeostasis. This study was undertaken to investigate changes in expression levels of stomach ghrelin as well as of ghrelin receptor in the hypothalamus and pituitary glands according to feeding state. Stomach ghrelin mRNA levels were increased by 48 h fasting but decreased by re-feeding. The ghrelin receptor mRNA levels of 48 h fasted rats were 8 times higher in the hypothalamus and 3 times higher in the anterior pituitary gland than levels in fed rats. In summary, not only stomach ghrelin, but also hypothalamic ghrelin receptor mRNA expression, increased during a fast. Such as enhanced ghrelin receptor expression could contribute to the amplification of ghrelin action in a negative-energy balance state.
胃饥饿素是一种新发现的肠道激素，与食物摄入调节和能量平衡有关。本研究旨在调查根据进食状态，胃中胃饥饿素以及下丘脑和垂体中胃饥饿素受体的表达水平变化。禁食48小时可使胃饥饿素mRNA水平升高，但重新进食后则降低。禁食48小时的大鼠下丘脑和垂体前叶中胃饥饿素受体mRNA水平分别是进食大鼠的8倍和3倍。总之，不仅胃饥饿素，而且下丘脑胃饥饿素受体mRNA表达在禁食期间也会增加。胃饥饿素受体表达增强可能有助于在负能量平衡状态下放大胃饥饿素的作用。
