特应性哮喘中的人类白细胞抗原II类基因频率：DRB101-DQB10501基因型与蒿属过敏哮喘的关联。

HLA class II genotypic frequencies in atopic asthma: association of DRB101-DQB10501 genotype with Artemisia vulgaris allergic asthma.

作者信息

Torío Alberto, Sánchez-Guerrero Immaculada, Muro Manuel, Villar Luisa María, Minguela Alfredo, Marín Luis, Moya-Quiles Maria Rosa, Montes-Ares Olga, Pagán Juan, Alvarez-López María Rocío

机构信息

Immunology Service, University Hospital "Virgen de la Arrixaca", Murcia, Spain.

出版信息

Hum Immunol. 2003 Aug;64(8):811-5. doi: 10.1016/s0198-8859(03)00109-5.

DOI:10.1016/s0198-8859(03)00109-5

PMID:12878360

Abstract

Different human leukocyte antigen (HLA) class II alleles have been associated with the development of atopic asthma. To determine whether HLA class II alleles are associated with atopic asthma in a population from southeast Spain (Murcia region), 213 atopic asthmatic patients and 150 controls were selected for HLA typing. Significant association of the DRB101 and DQB10501 alleles was found in Artemisia vulgaris allergic patients (p(c) = 0.00052 and p(c) = 0.00023, respectively). No significant correlation was found in other atopic patients allergic to pollens (Phleum pratense, Olea europaea, and Salsola kali), house dust mites (Dermatophagoides pteronyssinus, D. farinae), molds (Alternaria alternata, Cladosporium herbarum), or animal danders (dog, cat). The results reveal that the DRB101-DQB10501 genotype is strongly associated with a positive response to Artemisia vulgaris in the population studied.

摘要

不同的人类白细胞抗原（HLA）II类等位基因与特应性哮喘的发生有关。为了确定HLA II类等位基因是否与西班牙东南部（穆尔西亚地区）人群中的特应性哮喘有关，选择了213例特应性哮喘患者和150例对照进行HLA分型。在蒿属过敏患者中发现DRB101和DQB10501等位基因有显著关联（分别为p(c)=0.00052和p(c)=0.00023）。在其他对花粉（梯牧草、油橄榄、猪毛菜）、屋尘螨（粉尘螨、户尘螨）、霉菌（链格孢、草本枝孢）或动物皮屑（狗、猫）过敏的特应性患者中未发现显著相关性。结果显示，在研究人群中，DRB101-DQB10501基因型与对蒿属的阳性反应密切相关。