Purhonen S, Niskanen M, Wüstefeld M, Mustonen P, Hynynen M
Department of Anaesthesiology and Intensive Care, and Department of Surgery, Kuopio University Hospital, PO Box 1777, FIN-70211 Kuopio, Finland.
Br J Anaesth. 2003 Aug;91(2):284-7. doi: 10.1093/bja/aeg162.
Administration of supplemental oxygen 80% has been shown to halve the incidence of postoperative nausea and vomiting (PONV). We tested the efficacy of supplemental oxygen 50% in decreasing the incidence of PONV after breast surgery.
One hundred patients receiving standardized sevoflurane anaesthesia were randomly assigned to two groups: oxygen 30% administration (Group 30); and oxygen 50% administration (Group 50). Oxygen was administered during surgery and for 2 h from the end of surgery.
The incidence of PONV over 24 h after surgery showed no difference between the groups: 82% in Group 30 and 89% in Group 50. However, during the postoperative oxygen administration, eight patients vomited in Group 30, compared with none in Group 50 (P<0.05). After oxygen therapy ceased, there was no difference in the incidence of vomiting between the groups. Nausea and need for rescue antiemetics did not differ between the groups.
The incidence of vomiting decreased during the short postoperative administration of supplemental oxygen 50%. However, perioperative oxygen 50% administration did not prevent PONV over the 24-h follow-up period in patients undergoing breast surgery performed under general anaesthesia.
已证明给予80%的补充氧气可使术后恶心呕吐（PONV）的发生率减半。我们测试了50%的补充氧气在降低乳腺手术后PONV发生率方面的疗效。
100例接受标准化七氟醚麻醉的患者被随机分为两组：给予30%氧气（30%组）；给予50%氧气（50%组）。在手术期间及手术结束后2小时给予氧气。
术后24小时内PONV的发生率在两组之间无差异：30%组为82%，50%组为89%。然而，在术后给予氧气期间，30%组有8例患者呕吐，而50%组无呕吐发生（P<0.05）。停止氧气治疗后，两组之间呕吐发生率无差异。两组之间恶心及使用急救止吐药的情况无差异。
在术后短期给予50%补充氧气期间呕吐发生率降低。然而，在全身麻醉下进行乳腺手术的患者中，围手术期给予50%氧气并不能在24小时随访期内预防PONV。
