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编码大鼠主要组织相容性复合体II类RT1-Bu和RT1-Duα链及β链的互补DNA序列。

Complementary DNA sequences encoding the rat MHC class II RT1-Bu and RT1-Du alpha and beta chains.

作者信息

Easterfield Alistair J, Bradley J Andrew, Bolton Eleanor M

机构信息

Department of Surgery, University of Cambridge School of Clinical Medicine, Box 202, Addenbrooke's Hospital, Cambridge, CB2 2QQ, UK.

出版信息

Immunogenetics. 2003 Aug;55(5):344-50. doi: 10.1007/s00251-003-0584-7. Epub 2003 Jul 18.

DOI:10.1007/s00251-003-0584-7
PMID:12879310
Abstract

The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire sequence identity between five different inbred rat strains of the RT1u haplotype, which differs from previously published, incomplete sequences. This information is of considerable value for experimental studies of transplantation immunity and autoimmune disease.

摘要

大鼠主要组织相容性复合体基因座RT1 - B和RT1 - D分别等同于人类白细胞抗原HLA - DQ和HLA - DR。在此，我们描述了编码大鼠RT1u单倍型RT1 - B和RT1 - D基因座基因的α链和β链的互补DNA（cDNA）序列。我们发现RT1u单倍型的五个不同近交系大鼠之间存在完全的序列一致性，这与先前发表的不完整序列不同。该信息对于移植免疫和自身免疫性疾病的实验研究具有重要价值。

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本文引用的文献

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2
Limited polymorphism in the first domain of the rat MHC class II RT1-D molecule.大鼠主要组织相容性复合体II类RT1-D分子第一结构域的多态性有限。
Immunogenetics. 1998 Oct;48(5):344-9. doi: 10.1007/s002510050442.
3
Cytogenetic orientation of the rat major histocompatibility complex (MHC) on chromosome 20.
基因重复、平衡选择和跨物种进化解释了田鼠（仓鼠亚科）中MHC II类DQA基因的高度多态性。
Immunogenetics. 2006 Apr;58(2-3):191-202. doi: 10.1007/s00251-006-0085-6. Epub 2006 Feb 9.
4
Open reading frame sequencing and structure-based alignment of polypeptides encoded by RT1-Bb, RT1-Ba, RT1-Db, and RT1-Da alleles.RT1-Bb、RT1-Ba、RT1-Db和RT1-Da等位基因编码的多肽的开放阅读框测序及基于结构的比对。
Immunogenetics. 2004 Nov;56(8):585-96. doi: 10.1007/s00251-004-0725-7. Epub 2004 Oct 23.
大鼠主要组织相容性复合体（MHC）在20号染色体上的细胞遗传学定位
Immunogenetics. 1998;47(2):166-9. doi: 10.1007/s002510050342.
4
BB-DR/Edinburgh: a lymphopenic, non-diabetic subline of BB rats.BB-DR/爱丁堡：一种淋巴细胞减少、非糖尿病的BB大鼠亚系。
Immunology. 1993 Feb;78(2):318-28.
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Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex.大鼠自发性糖尿病综合征。I. 与主要组织相容性复合体的关联
J Exp Med. 1981 Oct 1;154(4):1237-42. doi: 10.1084/jem.154.4.1237.
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The mechanism of graft rejection and the concept of antigenic strength.移植排斥的机制及抗原强度的概念。
Scand J Immunol. 1981 Dec;14(6):687-91. doi: 10.1111/j.1365-3083.1981.tb00611.x.
7
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Immunogenetics. 1984;19(1):53-62. doi: 10.1007/BF00364475.
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