Ghysen Alain, Thomas René
Laboratoire de Neurogénétique, Université Montpellier II, France.
Bioessays. 2003 Aug;25(8):802-7. doi: 10.1002/bies.10311.
The genetic analysis of development has revealed the importance of small sets of interacting genes in most morphogenetic processes. The results of gene interactions have so far been examined intuitively. This approach is largely sufficient when one deals with simple interactions, a feedback circuit for example. As more components become involved, however, it is difficult to make sure that the intuitive approach gives a comprehensive view of the behaviour of the system. In this paper, we illustrate the use of a logical approach to describe the genetic circuit that underlies the singling out of sense organ precursor cells in Drosophila. We show how to apply logical modelling to a realistic problem, and how this approach allows an easy assessment of the dynamic properties of the system, i.e., of its possible evolutions and of its reactions to fluctuations and perturbations.
发育的遗传分析揭示了在大多数形态发生过程中，少量相互作用基因的重要性。到目前为止，基因相互作用的结果一直是通过直观方式进行研究的。当处理简单的相互作用时，比如一个反馈回路，这种方法在很大程度上是足够的。然而，随着涉及的组件越来越多，很难确保直观方法能全面呈现系统的行为。在本文中，我们阐述了如何使用逻辑方法来描述果蝇中感觉器官前体细胞分选背后的遗传回路。我们展示了如何将逻辑建模应用于一个实际问题，以及这种方法如何能够轻松评估系统的动态特性，即其可能的演化以及对波动和扰动的反应。
