Chipysheva T A, Gel'shteĭn V I, Ermilova V D, Vishnevskaia Ia V, Vasil'ev Iu M
N. N. Blokhin Cancer Research Center, 115478, Moscow.
Arkh Patol. 2003 May-Jun;65(3):3-7.
Distribution of cell-cell adhesion molecules of E-cadherin (EC) and beta-catenin (BC) infiltrating breast carcinoma (BC) and markers of epithelium, basal membrane has been studied by immunofluorescence in 50 infiltrating BC tissue samples including 17 ductal carcinomas, 23 lobular carcinomas and 10 combined carcinomas. Two types of EC-BC structure alterations were found: homogeneity disorder accompanied by appearance of local thickening and gaps or complete lack of these structures. Alterations of type 1 were found in all the analyzed samples of ductal and combined carcinomas and partially in lobular carcinomas, in in situ structures and in invasion components as well. Alterations of type 2 were found in 16 cases of lobular carcinomas of 23 examined. Our data suggest the existence of two groups of lobular BC: carcinomas with partial depletion of EC-BC structures and carcinomas which lost these structures. Further investigations are needed to evaluate clinical importance of the difference found.
通过免疫荧光法对50例浸润性乳腺癌组织样本（包括17例导管癌、23例小叶癌和10例混合癌）中E-钙黏蛋白（EC）和β-连环蛋白（BC）这两种细胞间黏附分子的分布以及上皮和基底膜标志物进行了研究。发现了两种类型的EC-BC结构改变：均匀性紊乱，伴有局部增厚和间隙的出现，或这些结构完全缺失。1型改变在所有分析的导管癌和混合癌样本中均有发现，小叶癌中部分样本、原位结构和侵袭成分中也有发现。2型改变在23例接受检查的小叶癌中有16例出现。我们的数据表明存在两组小叶乳腺癌：EC-BC结构部分缺失的癌和失去这些结构的癌。需要进一步研究以评估所发现差异的临床重要性。
