Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China 610041.
J Clin Anesth. 2012 Sep;24(6):456-9. doi: 10.1016/j.jclinane.2011.12.006. Epub 2012 Jul 2.
To compare the efficacy of pretreatment with parecoxib and lidocaine to prevent rocuronium injection pain.
Prospective, randomized, double-blinded study.
Academic medical center.
160 adult ASA physical status 1 and 2 patients scheduled for elective surgery.
Patients were randomly allocated to 4 groups of 40 patients each to receive pretreatment with normal saline (Group C), parecoxib 20 mg (Group P(20)), parecoxib 40 mg (Group P(40)), or lidocaine 40 mg (Group L). All groups underwent venous occlusion for two minutes before rocuronium was injected.
Pain scores were obtained by a study-blinded observer immediately after the pretreatment.
The frequency of rocuronium injection pain in the saline group (80%) was significantly higher than in Group P(20) (55%), Group P(40) (20%), and Group L (25%) (P < 0.05). The frequency and intensity of rocuronium-induced pain were statistically similar between Group P(40) and Group L. In the parecoxib 40 mg and lidocaine 40 mg groups, the frequency of pain was significantly less than in the parecoxib 20 mg group (P < 0.05).
Pretreatment with parecoxib and lidocaine was effective in reducing the frequency and severity of pain with rocuronium injection whereas pretreatment with parecoxib 40 mg and lidocaine 40 mg were the most effective treatments.
比较预先给予帕瑞昔布和利多卡因预防罗库溴铵注射痛的效果。
前瞻性、随机、双盲研究。
学术医疗中心。
160 例 ASA 分级为 1 级和 2 级的择期手术成年患者。
患者随机分为 4 组，每组 40 例，分别接受生理盐水（C 组）、帕瑞昔布 20mg（P(20)组）、帕瑞昔布 40mg（P(40)组）或利多卡因 40mg（L 组）预处理。所有组在注射罗库溴铵前均行静脉闭塞 2 分钟。
在预处理后即刻，由一位研究盲法观察者获取疼痛评分。
生理盐水组（80%）罗库溴铵注射痛的发生率显著高于 P(20)组（55%）、P(40)组（20%）和 L 组（25%）（P<0.05）。P(40)组和 L 组之间罗库溴铵诱导的疼痛的频率和强度具有统计学相似性。在帕瑞昔布 40mg 和利多卡因 40mg 组中，疼痛的发生率显著低于帕瑞昔布 20mg 组（P<0.05）。
预先给予帕瑞昔布和利多卡因可有效降低罗库溴铵注射痛的发生率和严重程度，而预先给予帕瑞昔布 40mg 和利多卡因 40mg 是最有效的治疗方法。
