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局灶节段性肾小球硬化中慢性肾衰竭的进展：足细胞损伤还是肾小管间质纤维化的结果？

Progression of chronic renal failure in focal segmental glomerulosclerosis: consequence of podocyte damage or of tubulointerstitial fibrosis?

作者信息

Kriz Wilhelm

出版信息

Pediatr Nephrol. 2003 Jul;18(7):617-22. doi: 10.1007/s00467-003-1172-7.

DOI:10.1007/s00467-003-1172-7
PMID:12879860
Abstract

The decline in renal function in chronic renal failure is based on the progressive loss of viable nephrons. The pathways to nephron loss in conjunction with chronic renal disease generally start in the glomerulus, extending onto the tubulointerstitium via the urinary pole. Pathways to nephron degeneration starting focally in the tubulointerstitium have yet to be described. The deleterious effects of protein leakage on progression appear to be a result of podocyte damage, the beneficial effects of ACE inhibitors a result of podocyte protection.

摘要

慢性肾衰竭中肾功能的下降是基于存活肾单位的逐渐丧失。与慢性肾脏疾病相关的肾单位丧失途径通常始于肾小球，通过尿极延伸至肾小管间质。尚未描述从肾小管间质局部开始的肾单位退变途径。蛋白质渗漏对疾病进展的有害影响似乎是足细胞损伤的结果，而ACE抑制剂的有益作用是足细胞保护的结果。

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