Chiriboga Ximena, Gilardoni Gianluca, Magnaghi Ilaria, Vita Finzi Paola, Zanoni Giuseppe, Vidari Giovanni
Facultad de Ciencias Quimicas, Universidad Central del Ecuador, Quito, Ecuador.
J Nat Prod. 2003 Jul;66(7):905-9. doi: 10.1021/np030066i.
Five new naturally occurring anthracene derivatives, 1,4,10-trimethoxyanthracene-2-carbaldehyde (1), (1,4,10-trimethoxy-2-anthracen-2-yl)methanol (2), 1,4,8,10-tetramethoxyanthracene-2-carbaldehyde (3), 1,4,10-trimethoxyanthracene-2-carboxylic acid (4), and 1,3-dimethoxy-2-methoxymethylanthraquinone (5), were isolated from Coussarea macrophylla along with three known compounds, 3-hydroxy-1-methoxy-2-methoxymethylanthraquinone (6), scopoletin, and 3-epi-pomolic acid. The structures of 1-5 were determined on the basis of analysis of their spectroscopic data and by total synthesis.
从大叶库萨草中分离出5种新的天然蒽衍生物，1,4,10-三甲氧基蒽-2-甲醛（1）、（1,4,10-三甲氧基-2-蒽基）甲醇（2）、1,4,8,10-四甲氧基蒽-2-甲醛（3）、1,4,10-三甲氧基蒽-2-羧酸（4）和1,3-二甲氧基-2-甲氧基甲基蒽醌（5），以及3种已知化合物，3-羟基-1-甲氧基-2-甲氧基甲基蒽醌（6）、东莨菪素和3-表-坡模酸。通过对其光谱数据的分析和全合成确定了1-5的结构。
