Coley Andrew M, Casey Joanne L
CRC for Diagnostics, Biochemistry Department, La Trobe University, Victoria, 3086, Australia.
Expert Opin Biol Ther. 2003 Aug;3(5):855-8. doi: 10.1517/14712598.3.5.855.
This meeting covered recent advances in the molecular display of peptides, proteins and nucleotides, including selection and mutational technologies. The scientific organisers assembled an impressive array of 'molecular display' heavyweights. It promised to be a stimulating meeting and the events of the following 2 days did not disappoint. The majority of the presentations were concerned with the development of novel display technologies and processes. Antibodies currently represent > 30% of the biopharmaceutical market, but are likely to be superseded by more efficient display frameworks which avoid their inherent drawbacks. In order to generate such novel therapeutics and diagnostics, high affinity reagents must be selected and/or generated from hitherto unexplored nucleic acid sequences and displayed on suitable frameworks. This meeting was concerned with the identification, generation and validation of novel sequences and framework molecules. The keynote addresses were followed by four themed sessions entitled New technologies and target selection, The discovery of small molecules using phage display, Applications in proteomics, and Novel therapeutics and diagnostics. There was a panel discussion after each session.
本次会议涵盖了肽、蛋白质和核苷酸分子展示的最新进展，包括筛选和突变技术。科学组织者召集了一批令人瞩目的“分子展示”领域的重量级人物。这有望成为一次令人振奋的会议，而接下来两天的会议情况也确实不负所望。大多数报告都围绕新型展示技术和方法的发展。抗体目前在生物制药市场中占比超过30%，但很可能会被更高效的展示框架所取代，因为这些框架能避免抗体固有的缺点。为了研发此类新型治疗药物和诊断方法，必须从尚未探索的核酸序列中筛选和/或生成高亲和力试剂，并将其展示在合适的框架上。本次会议关注的是新型序列和框架分子的鉴定、生成及验证。主题演讲之后是四个主题会议，分别为“新技术与靶点选择”“利用噬菌体展示发现小分子”“蛋白质组学中的应用”以及“新型治疗药物和诊断方法”。每个会议之后都有一场小组讨论。
