Casey Joanne L, Coley Andrew M
Department of Biochemistry, La Trobe University, Bundoora, Victoria 3086, Australia.
Expert Opin Biol Ther. 2003 Aug;3(5):859-62. doi: 10.1517/14712598.3.5.859.
The 4th Annual Recombinant Antibodies Conference was immediately following the 5th Annual 'Molecular Display: The Chemistry Set for Proteins and Small Molecules' conference, both held in Cambridge, MA and organised by Cambridge Healthtech Institute. The former conference focused on development of new approaches for recombinant antibody development, with particular emphasis on improved methods for selection and optimisation allowing rapid validation and development of human antibodies for the clinic. There were many impressive presentations describing emerging technologies such as new antibody-like scaffolds, covalent P2 antibody display, de-immunisation of antibodies and measuring affinities of as many as 400 clones simultaneously using proteomic microarray platforms. The conference also highlighted the latest applications of library technologies for proteomics and target discovery, and the generation of therapeutic molecules as antibodies alone or as drug, toxin or radionuclide conjugates.
第四届重组抗体年会紧接着第五届“分子展示：蛋白质和小分子的化学工具”年会召开，这两个会议均在马萨诸塞州剑桥市举行，由剑桥健康科技研究所组织。前一个会议聚焦于重组抗体开发新方法的进展，特别强调了改进的筛选和优化方法，这些方法能够实现人源抗体在临床中的快速验证和开发。会上有许多令人印象深刻的报告，介绍了新兴技术，如新型抗体样支架、共价P2抗体展示、抗体的去免疫化以及使用蛋白质组学微阵列平台同时测定多达400个克隆的亲和力。会议还重点介绍了文库技术在蛋白质组学和靶点发现方面的最新应用，以及单独作为抗体或作为药物、毒素或放射性核素偶联物的治疗性分子的生成。
