[负压吸引对兔视神经和视网膜的影响]
[Effect of negative pressure suction on rabbit optic nerve and retina].
作者信息
Ye A-Li, Pang Guo-xiang, Han Ye-hua
机构信息
Eye Research Center, Chinese Academy of Medical Sciences & Chinese Union Medical College, Department of Ophthalmology, Peking Union Medical College Hospital, Beijing 100730, China.
出版信息
Zhonghua Yan Ke Za Zhi. 2003 Mar;39(3):136-9.
OBJECTIVE
To study the effect of acute intraocular pressure (IOP) elevation on the optic nerve and retina in laser in situ keratomileusis (LASIK).
METHODS
Acute IOP was increased to 65 mm Hg for different period of time (30 s, 1 min and 3 min) by using scleral suction on rabbit eyes. The tissues of retina and optic nerve of immediately extirpated group (instant group), of 2 weeks later extirpated group (recovery group) both after the negative pressure suction and of normal rabbit eyes were examined with electron and light microscope.
RESULTS
After the negative pressure suction for 30 s, 1 min, and 3 min respectively, the optic nerve and retinal cells changed lightly; some part of optic nerve and retinal cells changed; optic nerve fibers and retinal cells changed sharply.
CONCLUSION
Ultrastructural changes of retina and optic nerve may be induced by acute IOP elevation in LASIK. The longer the time, the more apparent the changes.
目的
研究准分子原位角膜磨镶术（LASIK）中急性眼压升高对视神经和视网膜的影响。
方法
通过对兔眼进行巩膜抽吸，在不同时间段（30秒、1分钟和3分钟）将急性眼压升高至65毫米汞柱。对负压抽吸后立即摘除组（即刻组）、2周后摘除组（恢复组）以及正常兔眼的视网膜和视神经组织进行电子显微镜和光学显微镜检查。
结果
分别进行30秒、1分钟和3分钟的负压抽吸后，视神经和视网膜细胞轻度改变；视神经和视网膜细胞部分改变；视神经纤维和视网膜细胞明显改变。
结论
LASIK中急性眼压升高可能导致视网膜和视神经超微结构改变。时间越长，变化越明显。
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