Lin Y Y, Shih Y H, Hsieh J C, Yu H Y, Yiu C H, Wong T T, Yeh T C, Kwan S Y, Ho L T, Yen D J, Wu Z A, Chang M S
Integrated Brain Research Unit, Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Neuroimage. 2003 Jul;19(3):1115-26. doi: 10.1016/s1053-8119(03)00181-2.
To compare magnetoencephalography (MEG) with scalp electroencephalography (EEG) in the detection of interictal spikes in temporal lobe epilepsy (TLE), we simultaneously recorded MEG and scalp EEG with a whole-scalp neuromagnetometer in 46 TLE patients. We visually searched interictal spikes on MEG and EEG channels and classified them into three types according to their presentation on MEG alone (M-spikes), EEG alone (E-spikes), or concomitantly on both modalities (M/E-spikes). The M-spikes and M/E-spikes were localized with MEG equivalent current dipole modeling. We analyzed the relative contribution of MEG and EEG in the overall yield of spike detection and also compared M-spikes with M/E-spikes in terms of dipole locations and strengths. During the 30- to 40-min MEG recordings, interictal spikes were obtained in 36 (78.3%) of the 46 patients. Among the 36 patients, most spikes were M/E-spikes (68.3%), some were M-spikes (22.1%), and some were E-spikes (9.7%). In comparison with EEG, MEG gave better spike yield in patients with lateral TLE. Sources of M/E- and M-spikes were situated in the same anatomical regions, whereas the average dipole strength was larger for M/E- than M-spikes. In conclusion, some interictal spikes appeared selectively on either MEG or EEG channels in TLE patients although more spikes were simultaneously identified on both modalities. Thus, simultaneous MEG and EEG recordings help to enhance spike detection. Identification of M-spikes would offer important localization of irritative foci, especially in patients with lateral TLE.
为比较脑磁图（MEG）与头皮脑电图（EEG）在检测颞叶癫痫（TLE）发作间期棘波方面的差异，我们使用全头神经磁强计对46例TLE患者同时进行了MEG和头皮EEG记录。我们通过视觉在MEG和EEG通道上搜索发作间期棘波，并根据其在MEG单独出现（M波）、EEG单独出现（E波）或两种模式同时出现（M/E波）将它们分为三种类型。使用MEG等效电流偶极子模型对M波和M/E波进行定位。我们分析了MEG和EEG在棘波检测总体产出中的相对贡献，并比较了M波和M/E波在偶极子位置和强度方面的差异。在30至40分钟的MEG记录期间，46例患者中有36例（78.3%）记录到了发作间期棘波。在这36例患者中，大多数棘波为M/E波（68.3%），一些为M波（22.1%），一些为E波（9.7%）。与EEG相比，MEG在外侧TLE患者中棘波检出率更高。M/E波和M波的来源位于相同的解剖区域，而M/E波的平均偶极子强度大于M波。总之，尽管在TLE患者中更多的棘波在两种模式上同时被识别，但一些发作间期棘波选择性地出现在MEG或EEG通道上。因此，同时进行MEG和EEG记录有助于提高棘波检测。识别M波将为刺激性病灶提供重要的定位信息，尤其是在外侧TLE患者中。
