Wang Xiaohong, Inui Koji, Qiu Yunhai, Hoshiyama Minoru, Tran Tuan Diep, Nguyen Thi Binh, Kakigi Ryusuke
Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan.
Brain Res Cogn Brain Res. 2003 Jul;17(2):388-99. doi: 10.1016/s0926-6410(03)00140-x.
We investigated the effects of sleep on pain-related somatosensory evoked magnetic fields (SEFs) following painful electrical stimulation to identify the mechanisms generating them in both fast A-beta fibers relating to touch and slow A-delta fibers relating to pain. While the subjects were awake, non-painful and painful electrical stimulations were applied, and while asleep, painful stimulation was applied to the left index finger. During awake, five components (1M-5M) were identified following both non-painful and painful stimulation, but the 4M and 5M at around 70-100 ms and 140-180 ms, respectively, were significantly enhanced following painful stimulation. During sleep, 1M and 2M generated in the primary somatosensory cortex (SI) did not show a significant change, 3M in SI showed a slight but significant amplitude reduction, and 4M and 5M generated in both SI and the secondary somatosensory cortex (SII) were significantly decreased in amplitude or disappeared. The 4M and 5M are complicated components generated in SI and SII ascending through both A-beta fibers and A-delta fibers. They are specifically enhanced by painful stimulation due to an increase of signals ascending through A-delta fibers, and are markedly decreased during sleep, because they much involve cognitive function.
我们研究了睡眠对疼痛性电刺激后疼痛相关体感诱发磁场（SEFs）的影响，以确定在与触觉相关的快速A-β纤维和与疼痛相关的慢速A-δ纤维中产生这些磁场的机制。在受试者清醒时，施加非疼痛性和疼痛性电刺激，在睡眠时，对左手食指施加疼痛性刺激。清醒时，非疼痛性和疼痛性刺激后均识别出五个成分（1M-5M），但疼痛性刺激后，分别在70-100毫秒和140-180毫秒左右的4M和5M显著增强。睡眠期间，初级体感皮层（SI）产生的1M和2M没有显著变化，SI中的3M显示出轻微但显著的幅度降低，SI和次级体感皮层（SII）产生的4M和5M幅度显著降低或消失。4M和5M是在SI和SII中通过A-β纤维和A-δ纤维上升产生的复杂成分。它们因通过A-δ纤维上升的信号增加而在疼痛性刺激下特异性增强，并且在睡眠期间显著降低，因为它们大量涉及认知功能。
