Ozeki K, Yuhta T, Aoki H, Fukui Y
Applied Systems Engineering, Graduate school of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama, Hiki, Saitama, 350-0394, Japan.
Biomed Mater Eng. 2003;13(3):271-9.
To alleviate the effects of Ni allergy from NiTi alloy implants, hydroxyapatite (Ca10(PO4)6(OH)2; HA), alumina (Al2O3), or titanium (Ti) was coated onto NiTi alloy plates to form 1-microm thick films using radio frequency magnetron sputtering. The coatings on the plates were characterized using XRD. After the plates had been immersed in physiological saline for periods of one, four, or eight weeks, the concentration of Ni ions released in each solution was detected using a microwave induced plasma mass spectrometer. After eight weeks, the concentration of Ni ions released from the non-coated, the Ti-coated, the HA-coated, and the alumina-coated plates were 238, 19.7, 183, and 106 ppb, respectively. The bonding strength of the Ti film, the HA film, and the alumina film to the NiTi substrate were 3.8 +/- 1.2, 2.6 +/- 0.7, and 3.1 +/- 1.2 MPa, respectively. The non-coated, the HA-coated, the alumina-coated, and the Ti-coated plates were implanted into the femurs of a dog for four weeks for histological observation. In case of the non-coated plates, connective tissue more than 300 microm thick was observed, whereas for the coated plates the thickness of the connective tissue was around 100 microm.
为减轻镍钛合金植入物引起的镍过敏反应，采用射频磁控溅射法在镍钛合金板上涂覆羟基磷灰石（Ca10(PO4)6(OH)2；HA）、氧化铝（Al2O3）或钛（Ti），形成1微米厚的薄膜。用X射线衍射仪对板上的涂层进行表征。将这些板在生理盐水中浸泡1周、4周或8周后，用微波诱导等离子体质谱仪检测每种溶液中释放的镍离子浓度。8周后，未涂层、钛涂层、羟基磷灰石涂层和氧化铝涂层板释放的镍离子浓度分别为238、19.7、183和106 ppb。钛膜、羟基磷灰石膜和氧化铝膜与镍钛基体的结合强度分别为3.8±1.2、2.6±0.7和3.1±1.2 MPa。将未涂层、羟基磷灰石涂层、氧化铝涂层和钛涂层的板植入狗的股骨中4周进行组织学观察。对于未涂层的板，观察到结缔组织厚度超过300微米，而对于涂层板，结缔组织厚度约为100微米。
