Schulman F Y, Krafft A E, Janczewski T, Mikaelian I, Irwin J, Hassinger K
Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA.
J Zoo Wildl Med. 2003 Jun;34(2):179-83. doi: 10.1638/1042-7260(2003)034[0179:CFIAML]2.0.CO;2.
A 12-yr-old mountain lion (Felis concolor) developed a 0.5-cm3 raised nonpigmented and nonulcerated mass between the lip and the nasal planum. The tumor was surgically removed and diagnosed histologically as a fibropapilloma. The tumor recurred 1 yr later, at which time it was again excised, and the diagnosis was reconfirmed by biopsy. Frozen tissue from the second excision was submitted for polymerase chain reaction testing for papillomavirus. The 176-base pair polymerase chain reaction product recovered from the tumor was cloned and sequenced. The papillomavirus had 96% homology with a papillomavirus previously retrieved from a fibropapilloma in a domestic cat and is the next most closely related to bovine papillomavirus type 1. This is the first report of a virus-associated fibropapilloma in a mountain lion.
一只12岁的美洲狮（美洲狮属）在唇部和鼻平面之间长出了一个0.5立方厘米的凸起、无色素沉着且未溃疡的肿块。该肿瘤通过手术切除，组织学诊断为纤维乳头瘤。肿瘤在1年后复发，此时再次切除，并通过活检再次确诊。第二次切除的冷冻组织被送去进行乳头瘤病毒的聚合酶链反应检测。从肿瘤中回收的176个碱基对的聚合酶链反应产物被克隆并测序。该乳头瘤病毒与先前从家猫的纤维乳头瘤中提取的乳头瘤病毒有96%的同源性，是与1型牛乳头瘤病毒第二密切相关的病毒。这是关于美洲狮中病毒相关纤维乳头瘤的首次报告。
