一只来自马鹿（ Cervus elaphus ）的皮肤纤维乳头瘤，与乳头瘤病毒有关。

A cutaneous fibropapilloma from a red deer (Cervus elaphus) associated with a papillomavirus.

作者信息

Moar M H, Jarrett W F

出版信息

Intervirology. 1985;24(2):108-18. doi: 10.1159/000149626.

Abstract

A cutaneous fibropapilloma was found on a Scottish red deer (Cervus elaphus), and a papillomavirus was isolated from it. The virus appeared to be related to bovine papillomavirus type 1 (BPV1) or type 2 (BPV2) because: (i) it cross-reacted in peroxidase-antiperoxidase tests with antisera raised against these virions; (ii) BPV1 and BPV2 DNAs cross-hybridized to the red deer papillomavirus in situ; and (iii) BPV1 and/or BPV2 DNA cross-hybridized to the red deer papillomavirus DNA on Southern blots under conditions of high stringency. These tests also revealed a unique restriction enzyme cleavage pattern for the red deer papillomavirus DNA.

摘要

在一只苏格兰马鹿（ Cervus elaphus ）身上发现了一个皮肤纤维乳头瘤，并从中分离出一种乳头瘤病毒。该病毒似乎与牛乳头瘤病毒1型（BPV1）或2型（BPV2）有关，原因如下：（i）在过氧化物酶 - 抗过氧化物酶试验中，它与针对这些病毒粒子产生的抗血清发生交叉反应；（ii）BPV1和BPV2的DNA在原位与马鹿乳头瘤病毒发生交叉杂交；（iii）在高严格条件下，BPV1和/或BPV2的DNA在Southern印迹上与马鹿乳头瘤病毒DNA发生交叉杂交。这些试验还揭示了马鹿乳头瘤病毒DNA独特的限制性内切酶切割模式。