Gatsura S V, Gukasov V M
Biull Eksp Biol Med. 1992 Oct;114(10):380-1.
The effect of verapamil, nifedipine and sensit on the whole rat blood deoxygenation was studied by polarographic coulometry with consequent calculation of deoxygenation rate (DR) and blood deoxygenation constant (BDC). These drugs were studied in concentrations 10(-8)-10(-4) M according to their therapeutic range in vivo. Both verapamil and nifedipine significantly decreased DR, and the latter drug decreased BDC as well in concentration 2.9.10(-7) M. In contrast to verapamil and nifedipine, sensit caused mild, but statistically significant dose-related increase in DR with concomitant decrease in BDC. The data presented failed to establish relationships between chemical structure and deoxygenative effect of the drugs. Deoxygenation effect of sensit favours its administration in the treatment of ischemia-related arrhythmias.
采用极谱库仑分析法研究了维拉帕米、硝苯地平和sensit对大鼠全血脱氧的影响，并计算了脱氧率（DR）和血液脱氧常数（BDC）。根据这些药物在体内的治疗范围，研究了它们在10（-8）-10（-4）M浓度下的作用。维拉帕米和硝苯地平均显著降低了DR，且后者在浓度为2.9×10（-7）M时也降低了BDC。与维拉帕米和硝苯地平相反，sensit引起DR轻度但具有统计学意义的剂量相关增加，同时BDC降低。所呈现的数据未能确立药物化学结构与脱氧作用之间的关系。sensit的脱氧作用有利于其在治疗缺血相关心律失常中的应用。
