Scultéty S, Tamáskovits E
Department of Urology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Acta Physiol Hung. 1991;77(3-4):269-78.
Ca(2+)-antagonists change the contractility of isolated detrusor smooth muscle of rabbit influencing the translocation of intra- and extra-cellular Ca2+. This observation might be of clinical importance in the treatment of disorders of urinary bladder function. During field stimulation of different segments of isolated rabbit bladder it was found that the specific Ca(2+)-antagonist nifedipine and verapamil and the non-selective Ca(2+)-antagonist fendiline, prenylamine and cinnarizine blocked the contractions induced by field stimulus to different extent, which decreased from the bladder towards the bladder base (fundus). The highest rate of blocking effect was produced by nifedipine followed by verapamil, prenylamine and fendiline, respectively. Cinnarizine exerted the lowest effect. The change in amplitude and frequency of spontaneous peristalsis was similar in its tendency to the blockade of the field stimulus induced contraction.
钙拮抗剂通过影响细胞内和细胞外钙离子的转运来改变兔离体逼尿肌平滑肌的收缩性。这一观察结果在膀胱功能障碍的治疗中可能具有临床重要性。在对兔离体膀胱不同节段进行场刺激时发现，特异性钙拮抗剂硝苯地平、维拉帕米以及非选择性钙拮抗剂芬地林、普尼拉明和桂利嗪在不同程度上阻断了场刺激诱导的收缩，这种阻断作用从膀胱向膀胱底部（底部）逐渐减弱。硝苯地平产生的阻断作用率最高，其次分别是维拉帕米、普尼拉明和芬地林。桂利嗪的作用最低。自发性蠕动的幅度和频率变化在趋势上与场刺激诱导收缩的阻断相似。
