[达来argin对小鼠巨噬细胞5'-核苷酸酶活性及内源性血液皮质醇水平应激诱导变化的影响]
[The effect of dalargin on stress-induced changes in the 5'-nucleotidase activity of the macrophages and in the level of endogenous blood cortisol in mice].
作者信息
Kirillicheva G B, Mit'kin V V, Solov'eva M S, Zozulia A A, Shurin M R, Pshenichkin S F, Sukhikh G T
出版信息
Biull Eksp Biol Med. 1992 Oct;114(10):389-90.
PMID:1288698
Abstract
The action of dalargin, synthetic analogue of leuenkephaline, on stress-induced changes in 5'-nucleotidase activity and endogenous hydrocortisone levels was investigated in mice. It was found that there is a direct relation between the activity of 5'-nucleotidase and the level of hydrocortisone in CBA mice. For C57Bl/6 mice the relation was inverse. Dalargin is able to change the dependence from direct to opposite in CBA mice.
摘要
在小鼠中研究了亮氨酸脑啡肽的合成类似物达拉argin对压力诱导的5'-核苷酸酶活性变化和内源性氢化可的松水平的影响。发现CBA小鼠中5'-核苷酸酶活性与氢化可的松水平之间存在直接关系。对于C57Bl/6小鼠，这种关系是相反的。达拉argin能够使CBA小鼠中的这种依赖性从直接变为相反。
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