Kubba A K, Taylor P, Graneek B, Strobel S
Department of Occupational Medicine, Royal Marsden Hospital.
Commun Dis Public Health. 2003 Jun;6(2):106-12.
Hepatitis B virus (HBV) infection is a major public health issue throughout the world and vaccination of those at risk is the main method of containment. Of healthy vaccinees, 5-10% fail to mount an adequate antibody response. The antibody levels of an unknown further fraction of vaccinees fall considerably over time rendering them at a potential risk of infection. The scope of this article is to review the factors that might influence the immune response to HBV vaccination, to review the methods used to overcome the problem of poor response and to discuss what possible guidelines are available or needed in treating these vaccinees.
乙型肝炎病毒（HBV）感染是全球主要的公共卫生问题，对高危人群进行疫苗接种是控制该疾病的主要方法。在健康的疫苗接种者中，5%至10%的人未能产生足够的抗体反应。另有一部分未知比例的疫苗接种者的抗体水平会随着时间的推移大幅下降，使他们面临潜在的感染风险。本文的目的是回顾可能影响对HBV疫苗免疫反应的因素，回顾用于克服低反应问题的方法，并讨论在治疗这些疫苗接种者方面有哪些可用或需要的指导方针。
