毛发上皮瘤：细胞角蛋白的免疫组织化学研究
Trichilemmoma: an immunohistochemical study of cytokeratins.
作者信息
Kurokawa I, Nishijima S, Kusumoto K, Senzaki H, Shikata N, Tsubura A
机构信息
Department of Dermatology, Hyogo Prefectural Tsukaguchi Hospital, 6-8-17, Minamitsukaguchi-cho, Amagasaki, Hyogo 661-0012, Japan.
出版信息
Br J Dermatol. 2003 Jul;149(1):99-104. doi: 10.1046/j.1365-2133.2003.05304.x.
BACKGROUND
The histogenesis of trichilemmoma remains unclear.
OBJECTIVES
To clarify the histogenesis of trichilemmoma by evaluating its cytokeratin (CK) expression.
METHODS
In three cases of trichilemmoma, CK expression was studied immunohistochemically using seven antikeratin antibodies against CK1, 10, 14-17 and 19, respectively.
RESULTS
CK1 and CK10 were present in keratinizing ductal epithelium. CK14 was present in the whole layer. CK15 was present in suprabasal layers in two cases. CK16 was present in the suprabasal layer, but was absent in keratinizing ductal epithelium. CK17 was present in suprabasal layers and the sebaceous duct-like structure. CK19 was totally absent.
CONCLUSIONS
These results showed that trichilemmoma may differentiate mainly towards two directions: infundibular keratinization and proliferation of the outer root sheath with undifferentiated and pluripotent characteristics.
背景
外毛根鞘瘤的组织发生仍不清楚。
目的
通过评估细胞角蛋白（CK）表达来阐明外毛根鞘瘤的组织发生。
方法
对3例外毛根鞘瘤，分别使用7种抗角蛋白抗体（抗CK1、10、14 - 17和19）进行免疫组织化学研究CK表达。
结果
CK1和CK10存在于角化导管上皮中。CK14存在于全层。2例中CK15存在于基底层以上各层。CK16存在于基底层以上各层，但在角化导管上皮中不存在。CK17存在于基底层以上各层及皮脂腺导管样结构中。CK19完全不存在。
结论
这些结果表明，外毛根鞘瘤可能主要向两个方向分化：漏斗部角化和具有未分化及多能特性的外根鞘增殖。
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