Płachta Iga, Kleibert Marcin, Czarnecka Anna M, Spałek Mateusz, Szumera-Ciećkiewicz Anna, Rutkowski Piotr
Department of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie National Research Institute of Oncology, 02-781 Warsaw, Poland.
Faculty of Medicine, Medical University of Warsaw, 02-091 Warsaw, Poland.
Int J Mol Sci. 2021 Apr 30;22(9):4759. doi: 10.3390/ijms22094759.
Neoplasms derived from follicular tissue are extremely rare. Clinically, they are reported as non-symptomatic, slow-growing nodules. These lesions are mainly benign, but the malignant type can occur. Mainly middle-aged people (50-60 years of age) are affected. These carcinomas are mainly localized on the head and neck or torso. They can be locally aggressive and infiltrate surrounding tissue and metastasize to regional lymph nodes. In the minority of cases, distant metastases are diagnosed. Quick and relevant diagnosis is the basis of a treatment for all types of tumors. The patient's life expectancy depends on multiple prognostic factors, including the primary tumor size and its mitotic count. Patients should be referred to a specialized skin cancer center to receive optimal multidisciplinary treatment. This article tries to summarize all the information that is currently available about pathogenesis, diagnosis, and treatment methods of follicular tumors.
源自滤泡组织的肿瘤极为罕见。临床上，它们被报告为无症状、生长缓慢的结节。这些病变主要是良性的，但也可能出现恶性类型。主要受影响的是中年人（50至60岁）。这些癌主要位于头颈部或躯干。它们可能具有局部侵袭性，浸润周围组织并转移至区域淋巴结。在少数情况下，会诊断出远处转移。快速且相关的诊断是所有类型肿瘤治疗的基础。患者的预期寿命取决于多种预后因素，包括原发肿瘤大小及其有丝分裂计数。患者应转诊至专业的皮肤癌中心接受最佳的多学科治疗。本文试图总结目前关于滤泡性肿瘤的发病机制、诊断和治疗方法的所有可用信息。
