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与强毒突变病毒或强毒卫星RNA相关的病毒致病性增强与病毒粒子积累减少和游离衣壳蛋白丰度降低有关。

Enhanced viral pathogenesis associated with a virulent mutant virus or a virulent satellite RNA correlates with reduced virion accumulation and abundance of free coat protein.

作者信息

Zhang Fengli, Simon Anne E

机构信息

Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, MD 20742, USA.

出版信息

Virology. 2003 Jul 20;312(1):8-13. doi: 10.1016/s0042-6822(03)00345-3.

Abstract

SatC, a chimeric satellite RNA associated with Turnip crinkle virus (TCV), intensifies the symptoms of TCV on all symptomatic hosts yet attenuates the symptoms of a TCV mutant that expresses low levels of a defective coat protein (CP). We now report that TCV virion levels were substantially reduced by the presence of satC or when two amino acids were inserted at the N-terminus of the CP, resulting in similarly enhanced symptoms. Since the TCV CP is a suppressor of RNA silencing, increased levels of resultant free CP could augment silencing suppression, resulting in enhanced colonization of the plant.

摘要

SatC是一种与芜菁皱缩病毒(TCV)相关的嵌合卫星RNA,它会加剧TCV在所有有症状宿主上的症状,但会减轻表达低水平缺陷衣壳蛋白(CP)的TCV突变体的症状。我们现在报告,satC的存在或在CP的N端插入两个氨基酸时,TCV病毒粒子水平会大幅降低,导致症状同样增强。由于TCV CP是RNA沉默的抑制因子,由此产生的游离CP水平增加可能会增强沉默抑制,从而导致植物定殖增强。

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